Prior to the arrival of the First Fleet in 1788, the area of today’s Blacktown was inhabited by different groups of the Darug people including the Warmuli, based around what is now Prospect, and their neighbours the Gomerigal from the South Creek area and the Wawarawarry from the Eastern Creek area.

It is estimated that fifty to ninety percent of the Darug died of smallpox and other introduced diseases within a few years of the British arrival. Governor Arthur Phillip began granting land in the area to white settlers in 1791. In 1819 Governor Lachlan Macquarie granted land to two indigenous men, Colebee and Nurragingy as payment for their service to The Crown, for assisting Cox with the road over the Blue Mountains and in dealing with Aboriginal issues.

A post office was opened in 1862 and a school in 1877. In 1906, the Shire of Blacktown was formed and in 1930, electricity was introduced to the town. The population in 1933 was then around 13,000. In the 1950s and 1960s, there was a large amount of suburban development both in the current suburb of Blacktown and the new suburbs that sprung up around it. This led to civic development in the town centre with the hospital opening in 1965, the courthouse and police station in 1966, the library in 1967 and the TAFE college in 1969. In 1973, the Westpoint shopping centre opened which was soon followed by the cinema complex.